Second up for My little hoofbeast: Friendship is not a disease is Gamzee! :D
On the left is high Gamzee and on the right is sober Gamzee.
Explanation:
Well, some of it is self-explanatory. (The spots, the face paint...) but I'll explain most of it.
Well, on the left (let's start there) the neon-green marking on his hind foot is to represent the sopor that he ate. The cutie mark is there for the same reason. The face paint is there because he wore it. The spots are there because of his pants. :)
On the right, the markings (I swear, they are markings) represent, er, what he did. The reason his symbol changed is he was finally acting like his ancestor, the scratches are, well, his scratches. His eye changed color because of his eyes changing from yellow to dark orange, possibly to represent his going insane.
Now to do his God Tier. :D